http://148.72.244.84/xmlui/handle/123456789/17 2026-06-17T11:20:23Z http://148.72.244.84/xmlui/handle/xmlui/17170 Synthesis, Characterization and Biological activity of new Metal Complexes Derived From 4-Phenyl-3-thiosemicarbazide Noor Emad Abd Alrahman, Nasry Jassim Hussein The study involved the synthesis and characterization of the new compound 4-methoxy-N-(2-(phenylcarbamothioyl) hydrazine-1-carbonothioyl) benzamide (L). By combining the title ligand with metal ions of manganese (II), cobalt (II), and nickel (II), three transition metal complexes were synthesized. This reaction occurred through the combination of metal and ligand in a mole ratio of one-to-one utilizing ethanol as the solvent. The complexes generated have a chemical formula as follows: [LMnCl₂.H₂O], [LCoCl₂H₂O], and [LNiCl₂.H₂O]. A variety of physicochemical techniques have been utilized to demonstrate the entity of the predicted structure of the ligand and its metal complexes. including Fourier transform infrared spectroscopy, UV-Vis spectroscopy, (1H and 13C)-NMR, elemental analysis (C, H, N, S), content of chloride, content of metal, m.p., the molar conductivity measurements, and also magnetic susceptibility. Based on spectral and analytical data, the isolation complexes for the manganese (II), cobalt (II), and nickel (II) exhibit a six-coordinate with a distorted octahedral geometry. The antibacterial activity of the complexes was investigated against (G+) and (G-) bacteria 2025-12-30T00:00:00Z http://148.72.244.84/xmlui/handle/xmlui/17169 Metabolic Mechanisms of Fat Accumulation and Effects of a Healthy Lifestyle Intervention on Obesity Indicators in Adults A Case-Control Study Nour Shakir Rezaieg, Muthanna M. Awad Obesity is a complex condition resulting from a long-term positive energy balance, in which energy intake exceeds energy expenditure, leading to excessive accumulation of adipose tissue. This study evaluated the impact of a six-month healthy lifestyle intervention on anthropometric, metabolic, and lipid parameters among obese adults. Participants were divided into three groups: obese individuals pre-intervention, the same group post-intervention, and normal-weight controls. Body composition was measured, and lipid profile and metabolic parameters were assessed before and after the intervention. The study was designed as a quasi-experimental longitudinal controlled study, done from 2024 to 2025. The intervention included a healthy lifestyle program was designed for obese group. The results showed significantly higher body composition and metabolic indices in obese group compared to normal-weight individuals. Lipid profile were significantly higher (P<0.05), with the exception of high-density lipoprotein, which was low in the obese group before the intervention. Post-intervention, a significant decrease was observed in body compositions indicators, lipid profile, and metabolic indicators compared to the values recorded before the intervention. These values, however, remaining higher than the levels of healthy individuals. High-density lipoprotein increased slightly post-intervention, but did not reach the level of normal weight individuals. The results reflect the positive effect of fat loss on reducing chronic inflammation associated with obesity and improving metabolic and lipid profiles, confirming the effectiveness of a healthy lifestyle in obesity management. 2025-12-30T00:00:00Z http://148.72.244.84/xmlui/handle/xmlui/17168 Synthesis and Characterization of Novel Nitroaniline-Based Azo Compounds as Acid-Base Indicators Yazan Zuhair Abbas, Abdullah Hussein Kshash Nine new azo compounds (Y1-Y9) were synthesized in this work by diazotizing ortho-, meta-, and para-nitroaniline derivatives and then coupling them with either 2,7-dihydroxynaphthalene, 8-hydroxyquinoline, or α-naphthol. The reactions were carried out in an ice-bath at 0-5 °C under strictly regulated basic conditions. Using DMSO-d₆ as the solvent, Fourier transform infrared (FT-IR) and nuclear magnetic resonance (NMR) spectroscopy (¹H and ¹³C) were used to characterize the structures of all produced compounds definitively. UV-Vis spectral shifts in DMSO solutions across a wide pH range (1-14) were examined to measure their effectiveness as acid-base indicators. Both protonation and deprotonation caused noticeable bathochromic shifts in the compounds. The cationic form (pH 1-7) exhibited absorption maxima (λmax) at 391-483 nm, whereas the anionic form (pH 8-14) absorbed at 448-587 nm. These sharp and reversible color changes, which correspond to pH ranges of 7-10, demonstrate the effectiveness of the synthesized azo compounds as effective acid-base indicators in analytical chemistry, offering potential alternatives to conventional standards. 2025-12-30T00:00:00Z http://148.72.244.84/xmlui/handle/xmlui/17166 Alterations in Tryptophan Metabolic Pathways in Obese Individuals Adhering to Low-Carbohydrate Intermittent Fasting: Contributions to Oxidative Stress and Hypertension Nabaa Jawad Kadhim, Mustafa Taha Mohammed; Rulla Sabah Low-carbohydrate diets and intermittent fasting (IF) are increasingly used for weight control, particularly in obese women. Modifying dietary behavior forces the body to adapt alternative pathways for energy and nutrient supply. Obesity is associated with oxidative stress and hypertension due to excess body fat. Tryptophan (Trp), an essential amino acid, is metabolized mainly via the kynurenine, 5-hydroxytryptophan (5-HT), and indole pathways. This study examined the effects of lifestyle on Trp metabolism, focusing on the kynurenine and 5-HT pathways, and their association with oxidative stress and hypertension. A total of 120 premenopausal women were enrolled: 40 controls (BMI<25 kg/m²), 40 non-adherent obese (BMI≥30 kg/m²), and 40 obese adherent to low-carb and IF. Serum analyses included lipid profile, total oxidant status (TOS), total antioxidant capacity (TAC), 8-hydroxydeoxyguanosine (8-OHdG), kynurenine, and 5-HT. Non-adherent obese participants showed significantly higher TOS, 8-OHdG, and kynurenine, with lower TAC and Trp than controls. Adherent obese participants exhibited improvements in TOS, TAC, and kynurenine compared to non-adherent obese, though 8-OHdG and Trp remained unchanged. Oxidative stress correlated with kynurenine in non-adherent obese and with 5-HT in adherent obese. A metabolic shift from kynurenine to 5-HT was observed in the adherent group, negatively correlated with BMI. Kynurenine was associated with increased hypertension risk in both obese groups.In conclusion, adherence to a low-carb diet and IF can shift Trp metabolism from the kynurenine to the 5-HT pathway, reduce oxidative stress, and lower hypertension risk in obese premenopausal women, highlighting the metabolic benefits of lifestyle interventions beyond weight reduction. 2026-03-30T00:00:00Z