Evaluate the Seroprevalence of Human Papillomavirus Immunoglobulin IgM among Women and Its Relationship with Cervical Cancer In Diyala Governorate

Abstract

Background: Prolonged infections caused by High-risk HPVs have the potential to cause cancer in the regions of the body where they infect cells, including the cervix or the oropharynx, which refers to the rear part of the throat. Aims: To detection of Human Papillomavirus (HPV) -IgM , IL-10 and TNF among Iraqi women Methods: A total of 89 blood sample were collected from females with various cervical lesions and 40 blood samples were collected from apparently healthy along with a control group of 40 healthy females. The presence of Human Papillomavirus (HPV) -IgM, IL-10 and TNF in the collected samples was assessed using the ELISA technique. Results: The positivity rate of HPV IgM was 13.5%. This positivity was higher among individuals aged 40 or younger who had also been diagnosed with cervical cancer. The levels of IL-10 and TNF differed between the two groups. The mean ±SD of IL-10 levels was 2.223±0.412 for patients and 2.035±0.009 for healthy females, with a significant difference (P < 0.001). The mean ±SD of TNF levels was 2.650±0.765 for patients and 2.384±0.011 for healthy females, with a significant difference (P < 0.001).