The Toxic Effects on Lung Tissues in Albino Male Rabbits infected by Klebsiella pneumonia

Abstract

Klebsiella pneumoniae is an important member of the Klebsiella genus in the Enterobacteriaceae family. It is a type of bacteria that can survive with or without oxygen, not motile, has a rod-like shape, and is classified as gram-negative. Thirty male rabbits used in study and divided into three groups: 1st group (GI): given (1CC /animal) an oral dose of phosphate buffer saline (PBS) by a stomach tube as a control group for 60 days, 2nd group (GII): One dose weekly were given 1CC viable K. pneumonia (1 X 106 CFU/ml) orally by stomach tube for 60 days, 3rd group (GIII): twice dose weekly were given 1CC viable K. pneumonia (1 X 106 CFU/ml) orally by stomach tube for 60 days. After 60 day of experiment the tissue sample from lung were taken for pathological examination & stained by hematoxylin & eosin stain. The results in 2nd group showed edema, interstitial pneumonia, hemorrhage with ballooning emphysema, severe infiltration of mononuclear cells, congested of blood vessels with interstitial pneumonia, While in 3rd group showed emphysema, artery arteriosclerosis with granuloma, fibrosis of bronchus, hyperplasia of epithelium and alveoli atelectasis. The aim and importance of this to explain the effects of K. pneumonia on lung tissue after exposure orally.