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Title: | Detection of Human Herpesvirus Type-1 Antigen in Tissues of Oral Squamous Cell Carcinoma by Direct Immunofluorecent Assay |
Authors: | Najwa Ahmed Mohammed Areej Atiyah Hussein Ahlam Hameed Majeed |
Keywords: | Oral squamous cell carcinoma human herpesvirus type1 immunofluorescence |
Issue Date: | Jun-2015 |
Publisher: | University of Diyala - College of Medicine |
Abstract: | Background: Human herpesvirus is a large enveloped DNA virus and significant human pathogen. Many studies examined oral squamous cell carcinoma for herpes simplex virus and suggested an association with this virus; others have demonstrated human herpesvirus -1 DNA in different part of oral squamous cell carcinoma. Objective: To detect the human herpes virus -1 antigen in tissues of oral squamous cell carcinoma. Patients and methods: Fourty two formalin-fixed, paraffin embedded oral tissues blocks were collected from 30 patients with oral squamous cell and 12 individuals with apparently-healthy oral tissues from archives of histopathology laboratory of college of Dentistry -Baghdad University, during the period from 2010 till 2012. All samples were related to the period between 2004 to 2009. Human herpesvirus -1 antigen was detected by direct immunofluorecent assay (US biological, Cat. No. H2033-08E). Results: Among oral squamous cell carcinoma group, 26 formalin-fixed, paraffin embedded oral tissues blocks were found to contain HHV-1 antigen, this result constituted 86.7% of the total oral squamous cell carcinoma screened for HHV-1 antigen and 75% within apparently-healthy oral tissues. The age of patients ranged from (25-70) years with mean of 53.26 ±12.1years. The highest percentage 60% was diagnosed in the age above 50 years. The percentage in males (61.68%) was more than in females (38.31%). On the other hand there was no significant difference between viral infection, age and gender distribution, while significant correlation noticed with tumor differentiation. Conclusion: The detection of human herpesvirus -1 antigen in oral squamous cell carcinoma and apparently healthy control indicates virus with other factor such as chemicals and radiation, which play important role in the development of oral cancers |
URI: | https://djm.uodiyala.edu.iq/index.php/djm http://148.72.244.84:8080/xmlui/handle/xmlui/3054 |
ISSN: | Print ISSN 2219-9764 Online ISSN 2617-8982 |
Appears in Collections: | مجلة ديالى الطبية / Diyala Journal of Medicine |
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File | Description | Size | Format | |
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7- Najwa Ahmed Mohammed.pdf | 623.16 kB | Adobe PDF | View/Open |
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