Distribution of Antithyroid Peroxidase Antibody in Patients with Clinically Suspected Thyroid Dysfunction

Abstract

Background: Thyroid peroxide had been characterized as an integral membrane hemoprotein catalyzes thyroglobulin iodination as well as the coupling of the di-iodotyrosine residues in the thyroglobulin molecule to form thyroxine. The prevalence of Thyroid peroxide autoantibody varies in different types of thyroid gland diseases and is positive in 5-15% of healthy individuals higher in elderly, but mostly in low titers. Objective: The study was conducted to evaluate the relation between anti- Thyroid peroxide antibody and T3, T4, and TSH as thyroid function parameters in thyroid disease patients. Patients and Methods: In 526 individuals suspected of having thyroid disease, from January 2011 to October 2011 in Al-Yarmouk Teaching Hospital. Measurement of anti-Thyroid peroxide antibody (ELISA) and T3, T4, and TSH (RIA) was done. Results: Hyperthyroid patients constitute about 287 patients (54.56%) of total sample while 176 patients (33.46%) were hypothyroid and 63 individuals (11.98%) were euthroid.392 individuals (74.52% of the patients) were females while 134 (25.48%) were males. Our results confirm that 137 (26.05%) of the patients were Thyroid peroxide positive. 100 female patients (72.99%) and 37 male patients (27.01%). Levels of T3, T4, and TSH in individuals with negative and positive anti- Thyroid peroxide antibody were statically insignificant. Conclusion: A correlation between TSH, T4 andT3 levels and abnormal anti- Thyroid peroxide antibodies was not proved.