Multidrug Resistant Behavior Of P Mirabilis Isolated From patients Urinary Tract Infections

Abstract

The aim of this study was to isolate and identify of Proteus mirabilis from patients with UTI and eval-uate its sensitivity to commonly used antibiotics . Proteus mirabilis was isolated from 60 of 250 samples , (24%). Proteus mirabilis was absolute resistant to ampicillin, amoxicillin-clavulanic acid and trimethoprim -sulfamethoxazole. A total of 90% of Proteus mirabilis isolates were resistant to ceftriaxone, cefotaxime and cefixime; 80% were resistant to nitofurantoin and 70% were resistant to nalidixic acid. However, 90% of Proteus mirabilis showed a sensitivity to amikacin, 70 % to cefoxitin, 3% to nalidixic acid. Mini-mum resistance was reported toward ciprofloxacin ,1%. A (10%) of Proteus mirabilis were resistant to 9 out of 10 tested antibiotics at the same time including; Penicillins ( ampicillin, amoxicillin-clavulanic acid), extended-spectrum cephalosporins (ceftriaxone, cefotaxime, cefixime); fluoroquinolones (ciprofloxacin); pyrimidine inhibitor of dihydrofolate reductase (trimethoprim - sulfamethoxazole); nitrofurans (nitofuranto-in); quinilones (nalidixic acid). 90% of isolates were MDR. A 40% of Proteus mirabilis isolated from human with UTIs were resistant to 9 out of 10 antibiotics at the same time including; penicillins ( ampicillin, amoxicillin-clavulanic acid), extended-spectrum cepha-losporins (ceftriaxone, cefotaxime, cefixime); pyrimidine inhibitor of dihydrofolate reductase (trime-thoprim - sulfamethoxazole); nitrofurans (nitofurantoin); quinilones (nalidixic acid). An 80% of isolates were MDR. A (30%) of human UTIs isolates were resistant to 6 out of 10 antibiotics at the same time in-cluding; penicillins (ampicillin, amoxicillin-clavulanic acid), extended-spectrum cephalosporins (ceftriax-one, cefotaxime, cefixime); pyrimidine inhibitor of dihydrofolate reductase (trimethoprim - sulfamethoxa-zole ). A 60% of the isolates were MDR . A (20%) of Proteus mirabilis isolated from human with UTIs were resistant to 4 out of 10 antibiotics at the same time including; penicillins (ampicillin, amoxicillin-clavulanic acid), extended-spectrum cephalosporins (ceftriaxone ); pyrimidine inhibitor of dihydrofolate re-ductase (trimethoprim - sulfamethoxazole); . A $0% of the isolates were MDR. A (10%) of Proteus mira-bilis isolated from UTIs were resistant to 6 out of 10 antibiotics at the same time including; penicillins (ampicillin, amoxicillin-clavulanic acid), extended-spectrum cephalosporins (ceftriaxone); pyrimidine in-hibitor of dihydrofolate reductase (trimethoprim - sulfamethoxazole); nitrofurans (nitofurantoin); quinilo-nes (nalidixic acid). A 60% of the isolates were MDR. A (10%) isolate of Proteus mirabilis from human with UTIs were resistant to 5 out of 10 antibiotics at the same time including; penicillins (ampicillin, amoxicillin-clavulanic acid), extended-spectrum cephalosporins (ceftriaxone, cefotaxime); pyrimidine in-hibitor of dihydrofolate reductase(trimethoprim - sulfamethoxazole). A 50% of the isolates were MDR In conclusion : MDR represent a serious problem in clinical practice and required serious attention from clinicians and health authorities.