Role of Some Cytokines After Fracture Trauma in young and Old Patients

Abstract

Background: Immune factors are of the most important systems used by the human body to treat infections and repair the emergency disorders. Objective: During period from January 2018 to June 2018 collected serum from (50) patients with different fractures patients who attended fractures units in Al-Yarmouk teaching hospital /Iraq. and determine by Elisa the levels of IL-6, IL-10 and granulocyte-monocyte colony-stimulating factor (GM-CSF) in sera of patients with fractures in relation with their age groups, current study also included 50 people as a control group, which represented the distribution of patients and healthy people as groups of young and elderly as well as their division on the basis of gender as well as body mass index (BMI). Patients and Methods: Four milliliter of venous blood was withdrawn from all patients and healthy so to measure the level of interleukins ( IL-6, IL-10 and granulocyte-monocyte colony-stimulating factor (GM-CSF) ) in sera, by Elisa . Results: The study found that IL-6 means were significantly elevated in old and young fracture trauma patients (31.36±5.33 and 23.81±4.33 pg/ml) respectively as compared with healthy young and old control individuals. The study revealed that, GM-CSF level was significantly elevated in young fracture trauma patients (62.61±7.23 pg/ml) as compared with old fracture trauma patients and healthy individuals and GM-CSF level was significantly elevated in old fracture trauma patients (27.18±4.87 pg/ml) as compared with old healthy individuals. IL-10 means were significantly elevated in young and old fracture trauma patients (3.51±0.28 and 2.29±0.31 pg/ml) respectively as compared with healthy young and old control individuals (2.18±0.27 and 1.99±0.18 pg/ml) respectively. Conclusion: The study showed positive correlation of IL-6, CM-CSF and IL-10 with BMI of young and old with fracture trauma.