Preparation and Characterization of 7-[2-Amino – 1,3,4 Thiadiazole – 5 – yl – Dithio Acetamido] Desacetoxy Cephalosporanic Acid Complexes with Fe(III), Ti(III) and Cr(III) ions

Abstract

The synthesis and characterization of new complexes of Fe3+ , Ti3+ and Cr3+ with the ligand of 7-[2-amino - 1,3,4 - thiadiazole - 5 - yl - dithio acetamido] desacetoxy cephalosporanic acid (cephalo H) in both neutral and basic medium were described. The complexes are of the general formula [M (cepahlo H) Cl2] Cl and [M (cephalo H) Cl2] [where M = Fe3+, Ti3+ and Cr3+; cephalo H = 7-[2-amino - 1,3,4 - thiadiazole - 5 - yl - dithio acetamido] desacetoxy cephalosporanic acid; cephalo = deprotonated of cephalo H. They are characterized by elemental analysis, molar conductivity and infrared spectrum. The ligand exhibited a tetradentate manner forming the most probable hexacoordinated geometry.