Synthesis of Some New Barbiturate Derivatives Via Schiff Bases

Abstract

A stable Schiff bases were prepared by condensation reaction between equimolar quantities of aromatic aldehydes with aromatic amines. Aromatic Schiff bases were undergo nucleophilic addition with acetyl chloride to give N-(chloro(phenyl)methyl)-N phenylacetamides. The reaction of latter with diethylmalonate in basic medium yeild diethyl 2-(phenyl(N-phenylacetamido)methyl)malonates. The latter condense with urea in basic medium to give derivatives of barbiturate which used in the medical field as hypnotics. The prepared compounds were identified by FT.IR and UV-Vis spectroscopy.