Leptin Level in Type 1 Diabetic and non Diabetic Post-puberty Overweight Iraqi Women

Abstract

Leptin is a circulating poly-peptide hormone (product in human ob gene) increased in obese individuals ,it appears that leptin decrease food intake and it play an important role in reproductive system , body homeostasis and metabolism .Significant correlation have been found between leptin and sexual hormones . The aim of this study was to measure the level of leptin in high Body Mass Index (BMI) , and its effect on estrogen and plasma glucose in healthy and diabetic overweight post-puberty women ,as far as we know that there is no such data comparing leptin ,estrogen and plasma glucose in healthy and diabetic women in Iraq .We divided our study subjects into three groups: First, 20 more than 30 kg/ m² non-diabetic women. Second, diabetic post-puberty women. Third,15 normal weight post-puberty women as control. A significant correlation between leptin and BMI ,estrogen and plasma glucose (increasing) P<0.05 between overweight and control normal weight women. Significant difference P<0.05 also found between diabetic and healthy overweight women in plasma glucose (increased), as well as a non significant differences P<0.05 has found between diabetic and healthy overweight women in leptin and estrogen levels. In conclusion: leptin goes hand by hand with BMI . Leptin cause an increase in estrogen and plasma glucose in diabetic and non diabetic overweight women comparing with normal weight women.