Role of Osteoprtegerin levels in a sample of Iraqi diabetic foot patients

Abstract

Diabetic foot (DF) is serious diabetes (DM) complication leading to delayed wound healing and may result in amputation. Osteoprotegerin (OPG) is a glycoprotein decoy receptor of RANKL(OPGL), involvement of OPG in the pathogenesis of diabetic complications has been proposed. Interactions OPG/OPGL has been proposed to be a major inhibiter of osteoclastogenesis (differentiation of osteoclasts cells),and OPG also has a role in the regulation of the immune response . This study was done to investigate whether the serum levels of circulating soluble osteoprotegerin, glycoprotein associated with the apoptosis, are altered in patients with type 2 diabetes whom have diabetic foot ulcerations. Osteoprotegerin was measured with the ELISA method in thirty (30) normal controls (group I), twenty five patients with type 2 DM (duration ranged from 1-32 years (group II) and in twenty five diabetic foot patients with type 2 DM (duration ranged from 2-31 years (group III). Also, serum glucose (Fasting), lipid profile (total cholesterol, triacylglycerol, HDL-c, LDL-c and VLDL-c) and hs-CRP were determined after 12hrs of fasting