Preparation and Characterization of Amino Acetylene Derivative by Mannich Reaction

Abstract

A short procedure for preparation of {4-[17-(1,5-Dimethyl-hexyl)-10,13-dimethylhexadecahydro-cyclopenta[a]phenanthren-3-yloxy] –but -2-ynylamino}-acetaldehyde)(3) from reaction of terminal acetylene with N-(diphenylmethylene) glycinates (2) is described. The reaction of terminal acetylene with compound (2) promoted by amino acid gave the dehydroamino acids containing secondary amine in good yield with aldehyde in presence of CuCl via microwave technique according to Mannich reaction .The compound(2) was prepared by refluxing cholesterol with propargyl bromide in dilute ethanolic potassium hydroxide solution at 70 oC .All compounds were characterized by means of their FT.IR spectra data and melting points.