A sensitive spectrophotometer method for the determination of 4-aminoantipyrine as a Schiff base complicated with Cr (III), Ni (II) &Cu (II) transition elements and its preparation

Abstract

A sensitive spectrophotometer method for the determination of 4-aminoantipyrine in pure as well as in pharmaceutical dosage form is reported, based on the preparation of Schiff base as a chalet ligand by condensation reaction of 4-aminoantipyrine with Isatin to give (1-phenyl-2,3dimethyl-4Isatidine-5-oxopyrazole) followed by the preparation of three new complexes for this ligand with Cr(III),Ni(II),and Cu(II) in alcoholic media. These prepared complexes were characterized by C.H.N.,F.T.I.R.,electronic spectra,molar conductivity,magnetic sensitivity and measurements of metal ratio by flame atomic absorption technique.Beer's law was obeyed in the concentration ranges (5-400) µg.ml-1,(7-300) µg.ml-1&(10-250) µg.ml-1 with a detection limit(D.L) of (0.18) µg.ml-1,(0.25) µg.ml-1&(0.33) µg.ml-1 for Cr(III),Ni(II) & Cu(II) respectively. The method was successfully applied for the assay of pharmaceutical tables (Ampyrone).