Inhibition of swarming and some virulence factors expression i n Proteus mirabilis by amikacin in vitro

Abstract

The effect of amikacin on proteuse mirabilis virulence factors expression were examined. Exposure of bacterial cell to different concentrations of amikacin caused inhibition of swarming ability of P. mirabilis. The expression of virulence factors heamolysin was aiso inhibited by amikacin. It was found that amikacin at concentration 2µ/ml could inhibit swarming activities, the production of urease and haemolysin was not affected by low concentration of amikacin but was inhibited by high concentration of it. These results indicate the impact of amikacin on the virulence factors with P.mirabilis isolate.