Abstract:
Fifty (50) serum samples were collected from patients with chronic hepatitis B (CHB) who
were admitted to Hepatology and Gastroenterology Teaching Hospital in Baghdad, aged from
20-65 years during the period from February / 2008 and the mid of February / 2009, also serum
samples were collected from Fifty (50) healthy HBs Ag carrier was discovered accidentally
through attending blood bank for donation of blood, aged from 18-52 years and served as a
control group. In this study, the serum levels of immunoglobulins (Igs) including IgG ,IgM ,
IgA are evaluated in both groups . The results review that the median level of IgG and IgA is
higher significantly in chronic patients than carrier group, whereas the median level of IgM is
slightly increase in chronic patients than carrier group, on other hand, the serum complement
components (C3 and C4) were evaluated in CHB patients in comparison to carrier group. It was
found that there was a significant decrease in the levels of C3 and C4 among chronic group
compared to carrier group. The results of this study indicate that serum complement and
immunoglobulins activities was impaired in chronic hepatitis B patients.
