Abstract:
In this search, we take the direct reaction line between the aromatic aldehydes & aromatics
ammines for reaction in Microwave technique to obtain clean and safe chemistry with very
short time and high products, high purity comparative with the thermal method (Reflux).
The above compounds allowed to reaction to produce (hydrazon) or which named (Schiff
bases) compounds (1, 3, 5, 7, 9).
The last step is cyclization step by irradiation with Microwave too, by reaction between
hydrazon compounds, and phthalic anhydride to produce the (1, 3 – Oxazepine) new
derivatives (2, 4, 6, 8, 10) as a final compounds, which employed in medical and
pharmaceutical research’s.
The prepared compounds were identified using melting point apparatus, Infrared
Spectroscopy; the results are agreement with the proposed assigned to the synthesized
compounds.