Abstract:
In this work: Oxazole derivative (1) were prepared from reaction histidine with acetic
anhydride ,which on treatment with thiosemicarbazide afford Schiff bases (2),and then two
methods are used for Schiff bases fusion ,one of them fusion to obtained imidazole derivative
(3) ,while the other method treatet with chloro ethyl acetate to obtained oxoimidazole
derivative (4).Imidazole derivative(5) were prepared by fusion oxazole derivtive (1) with ophenylene diamine. Finally oxazole dreivative (1) treated with hydrazine hydrate gave
imidazole derivative (6),which on treatment with aldehyde afford Schiff bases (7a,7b). The
structure of the newly synthesized compounds was confirmed by M.p, elemental analysis, IR
spectral data. All these synthesized compounds showed in Scheme (1)