New Study on the Effect of Scopoletin and Silver Nanoparticles of Fenugreek Extract as Pancreatic Cancer Inhibition Agents

Abstract

Pancreatic cancer is a highly aggressive and lethal form of cancer with limited treatment options. Therefore, exploring novel therapeutic strategies is crucial to improve patient outcomes. Researchers are currently investigating the potential therapeutic effects of scopoletin and silver nanoparticles on pancreatic cancer patients, The researchers focused on pancreatic cancer and conducted experiments involving the synthesis and characterization of silver nanoparticles. They utilized fenugreek extract to create these nanoparticles and tested various concentrations of both the nanoparticles and scopoletin. The purpose was to evaluate the potential anti-cancer and anti-angiogenic effects of these substances.The aim of this researchis to identify the most effective dose that can reduce the levels of cyclooxygenase-2 (COX-2) and lactate dehydrogenase (LDH), which are markers associated with cancer progression.The study was performedin vitro, The samples were categorized into three distinct groups. The control group, comprising 30 samples, consisted of healthy individuals of both genders, aged between 23 and 45 years. The second group consisted of 30 male and female patients, aged between 45 and 65 years, who were diagnosed with stage II pancreatic cancer. Lastly, the third group was composed of 30 male and female patients with stage III pancreatic cancer, aged between 52 and 79 years.In this study, it was discovered that patients with stage II and stage