The Influence of some Anti-pyretic and Anti-inflammatory Drugs on the Activity of Lactate Dehydrogenase ; Kinetic Study.

Abstract

Lactate dehydrogenase (LDH) is an enzyme EC (1. 1.1.27) that functions in anaerobic glucose metabolism and glucose synthesis (1). LDH is present in a wide variety of organisms including plants and animals (2). LDH has known effectors like lactate , pyruvate, NAD+, NADH, pH, buffers composition, ionic strength(4), fructose 1,6 bisphosphate, divalent cations such as Mn2+ or Co2+ (5). Proline and trimethylamine oxid (2µ) also affect the activity of LDH(6). Drugs like antipyretic and anti-inflammatory were reported to affect lactate dehyydrogenase activity (7,8).