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http://148.72.244.84:8080/xmlui/handle/xmlui/3525
Title: | Immunohistochemical Expression of Antioxidant Enzyme PRDX6 in Oral Squamous Cell Carcinoma In Relation to Clinicopathological Parameters |
Authors: | Mustafa Gheni Taher Wasan Hamdi Younis Muna Salih Merza |
Keywords: | Oxidative stress PRDC 6 squamous cell carcinoma |
Issue Date: | يون-2018 |
Publisher: | University of Diyala - College of Medicine |
Abstract: | Background:The PRDX6 antioxidant family is important in the protection of cells against oxidants in humans. It is encoded by the PRDX6 gene. Peroxiredoxin 6 antioxidant enzyme (PRDX 6) has been reported in several cancers. However, the function of PRDX 6 in oral squamous cell carcinoma (OSCC),is far from being understood. Objective:To normal corresponding oral mucosa in relation to clinicopathological parameters. Patients and Methods: This study included 40 formalin-fixed, paraffin-embedded tissue blocks of primary OSCC cases and fifteen normal oral mucosa samples. Demographic data, clinical staging and histopathological grading were obtained. Immunohistochemically staining anti PRDX 6 antibody was done to illustrate its subcellular localization in normal and malignant cells. Results: Females were affected more than males and the tongue was the most common site involved. PRDX 6 expression was high in OSCC than normal (p=0.001) with mean±Sd (60±18.8) (23±9.8). Significant correlations were found with tumor size, lymph node and tumor stage (p=0.008, p=0.012, p=0.011 respectively) . Whereas no relation was observed concerning age, gender and tumor site. Conclusion: Significant correlation of PRXD 6 anti oxidant enzyme expression with tumor size, lymph node involvement and clinical staging, suggesting its role in oral squamous cell carcinoma progression. |
URI: | https://djm.uodiyala.edu.iq/index.php/djm http://148.72.244.84:8080/xmlui/handle/xmlui/3525 |
ISSN: | Print ISSN 2219-9764 Online ISSN 2617-8982 |
Appears in Collections: | مجلة ديالى الطبية / Diyala Journal of Medicine |
Files in This Item:
File | Description | Size | Format | |
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11-Mustafa Ghany.pdf | 842.67 kB | Adobe PDF | View/Open |
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