Abstract:
Background: Non-alcoholic fatty liver disease (NAFLD) is a metabolic
liver disease characterized by a broad range of liver pathology, including
simple steatosis, steatohepatitis (NASH), fibrosis, cirrhosis, and
hepatocarcinoma. NAFLD has emerged as a public health concern in the
world within the last 20 years, it is linked to metabolic syndrome (MetS),
type 2 diabetes mellitus (T2DM), obesity, and dyslipidemia. Increased
visceral adipose tissue in obese people can cause insulin resistance (IR) and
hyperinsulinemia, which will speed up the lipolysis of adipose tissue, Lipo toxicity-related chronic low-grade inflammation is involved in the
development of NAFLD.
Objective: Determine the correlation between lipid profile and liver
function in patients with NAFLD.
Patients and Methods: A study was conducted at Tikrit Teaching Hospital
from 28 November to 28 December 2023. The study involved 90
participants, 60 with NAFLD and 30 healthy subjects. The study used a
spectrophotometer (Model NO. HV-2800EX) and a colorimetric kit from
Spain linear chemicals to determine various parameters, such as Aspartate
aminotransferase (AST), Alanine aminotransferase(ALT), Gamma glutamyl transferase(GGT), High-density lipoprotein(HDL), Low-density
lipoprotein(LDL), Very low-density lipoprotein(VLDL), Triglyceride(TG),
and cholesterol.
Results: The mean age of patients in the group was 40.93 years, with ages
ranging from 20 to 50 years. Serum levels of liver function enzymes (GGT,
AST, ALT) and lipid profile (TG, HDL, LDL, VLDL, cholesterol) were
measured and compared to the control groups. Patients with NAFLD had
significantly higher serum liver function enzymes and increased serum lipid
profile (TG, VLDL, LDL, and cholesterol) while showing a significant
decrease in HDL concentration when compared to the control group.
Conclusion: The patients showed an increase in liver function enzymes
(AST, ALT, GGT) and lipid profile (LDL, VLDL, TG, cholesterol) with
reduced HDL as compared to healthy individuals.
